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Research Article
Open Access

The Sociogenomics of Polygenic Scores of Reproductive Behavior and Their Relationship to Other Fertility Traits

Melinda C. Mills, Nicola Barban, Felix C. Tropf
RSF: The Russell Sage Foundation Journal of the Social Sciences April 2018, 4 (4) 122-136; DOI: https://doi.org/10.7758/RSF.2018.4.4.07
Melinda C. Mills
aNuffield Professor of Sociology at the University of Oxford and Nuffield College and leads the Sociogenome project, University of Oxford, OX1 3UQ United Kingdom
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  • For correspondence: melinda.mills@nuffield.ox.ac.uk
Nicola Barban
bSenior research associate in the Department of Sociology at the University of Oxford and Nuffield College
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  • For correspondence: nicola.barban@sociology.ox.ac.uk
Felix C. Tropf
cPostdoctoral researcher in the Department of Sociology at the University of Oxford and Nuffield College
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  • For correspondence: felix.tropf@sociology.ox.ac.uk
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REFERENCES

  1. ↵
    1. Ajzen, Icek.
    1991. “The Theory of Planned Behavior.” Organizational Behavior and Human Decision Processes 50(2): 179–211.
    OpenUrlCrossRefWeb of Science
  2. ↵
    1. Balbo, Nicoletta, and
    2. Nicola Barban.
    2014. “Does Fertility Behavior Spread Among Friends?” American Sociological Review 79(3): 412–31.
    OpenUrlCrossRef
  3. ↵
    1. Balbo, Nicoletta,
    2. Francesco C. Billari, and
    3. Melinda C. Mills.
    2013. “Fertility in Advanced Societies: A Review of Research.” European Journal of Population/Revue Européenne de Démographie 29(1): 1–38.
    OpenUrlCrossRefPubMed
  4. ↵
    1. Barban, Nicola,
    2. Rick Jansen,
    3. Ronald de Vlaming,
    4. Ahmad Vaez, et al, .
    2016. “Genome-Wide Analysis Identifies 12 Loci Influencing Human Reproductive Behavior.” Nature Genetics 48(12): 1462–72.
    OpenUrlCrossRefPubMed
  5. ↵
    1. Begall, Katia, and
    2. Melinda Mills.
    2013. “The Influence of Educational Field, Occupation, and Occupational Sex Segregation on Fertility in the Netherlands.” European Sociological Review 29(4): 720–42.
    OpenUrlCrossRef
  6. ↵
    1. Bhrolcháin, Maire Ni, and
    2. Éva Beaujouan.
    2012. “Fertility Postponement Is Largely Due to Rising Educational Enrolment.” Population Studies 66(3): 311–27.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Boivin, Jacky,
    2. Laura Bunting,
    3. John A. Collins, and
    4. Karl G. Nygren.
    2007. “International Estimates of Infertility Prevalence and Treatment-Seeking: Potential Need and Demand for Infertility Medical Care.” Human Reproduction 22(6): 1506–12.
    OpenUrlCrossRefPubMedWeb of Science
  8. ↵
    1. Brewster, Karin L., and
    2. Ronald R. Rindfuss.
    2000. “Fertility and Women’s Employment in Industrialized Nations.” Annual Review of Sociology 26(1): 271–96.
    OpenUrlCrossRefWeb of Science
  9. ↵
    1. Briley, Daniel A.,
    2. Felix C. Tropf, and
    3. Melinda C. Mills.
    2017. “What Explains the Heritability of Completed Fertility? Evidence from Two Large Twin Studies.” Behavior Genetics 47(1): 36–51.
    OpenUrl
  10. ↵
    1. Bulik-Sullivan, Brendan K.,
    2. Po-Ru Loh,
    3. Hilary K. Finucane,
    4. Stephan Ripke, et al, .
    2015. “LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies.” Nature Genetics 47(3): 291–95. DOI: 10.1038/ng.3211.
    OpenUrlCrossRefPubMed
  11. ↵
    1. Courtiol, Alexandre,
    2. Felix C. Tropf, and
    3. Melinda C. Mills.
    2016. “When Genes and Environment Disagree: Making Sense of Trends in Recent Human Evolution.” Proceedings of the National Academy of Sciences 113(28): 7693–95.
    OpenUrlFREE Full Text
  12. ↵
    1. Cox, David R.
    1972. “Regression Models and Life-Tables.” Journal of the Royal Statistical Society. Series B (Methodological) 34(2): 187–220.
    OpenUrlWeb of Science
  13. ↵
    1. Euesden, Jack,
    2. Cathryn M. Lewis, and
    3. Paul F. O’Reilly.
    2014. “PRSice: Polygenic Risk Score Software.” Bioinformatics 31(9): btu848–1468. Accessed August 21, 2017. http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bioinformatics/btu848.
    OpenUrl
  14. ↵
    1. Felson, Jacob.
    2014. “What Can We Learn from Twin Studies? A Comprehensive Evaluation of the Equal Environments Assumption.” Social Science Research 43 (January): 184–99. Accessed May 11, 2017. http://www.sciencedirect.com/science/article/pii/S0049089X13001397.
    OpenUrlCrossRefPubMed
  15. ↵
    Fisher, Ronald A. 1930. The Genetical Theory of Natural Selection. Oxford: Oxford University Press.
  16. ↵
    1. Heckman, James J.
    1974. “Effects of Child-Care Programs on Women’s Work Effort.” Journal of Political Economy 82(2): 136–63.
    OpenUrlCrossRef
  17. ↵
    1. Juster, F. Thomas, and
    2. Richard Suzman.
    1995. “An Overview of the Health and Retirement Study.” Special Issue, Journal of Human Resources 30: S7–56.
    OpenUrl
  18. ↵
    1. de Kaa, Dirk J. Van.
    1987. “Europe’s Second Demographic Transition.” Population Bulletin 42(1): 1–59.
    OpenUrlPubMed
  19. ↵
    1. Klijs, Bart,
    2. Salome Scholtens, and
    3. Jornt J. Mandemakers.
    2015. “Representativeness of the LifeLines Cohort Study.” PloS one 10(9): e0137203.
    OpenUrlCrossRefPubMed
  20. ↵
    1. Kohler, Hans-Peter,
    2. Joseph L. Rodgers, and
    3. Kaare Christensen.
    1999. “Is Fertility Behavior in Our Genes? Findings from a Danish Twin Study.” Population and Development Review 25(2): 253–88.
    OpenUrlCrossRefWeb of Science
  21. ↵
    1. Leridon, Henri.
    2008. “A New Estimate of Permanent Sterility by Age: Sterility Defined as the Inability to Conceive.” Population Studies 62(1): 15–24.
    OpenUrlPubMed
  22. ↵
    1. Lichtenstein, Paul,
    2. Patrick F. Sullivan,
    3. Sven Cnattingius,
    4. Margaret Gatz, et al, .
    2006. “The Swedish Twin Registry in the Third Millennium: An Update.” Twin Research and Human Genetics 9(6): 875–82.
    OpenUrlCrossRefWeb of Science
  23. ↵
    1. Manolio, Teri A.,
    2. Francis S. Collins,
    3. Nancy J. Cox,
    4. David B. Goldstein, et al, .
    2009. “Finding the Missing Heritability of Complex Diseases.” Nature 461(7265): 747–53.
    OpenUrlCrossRefPubMedWeb of Science
  24. ↵
    1. McDonald, Peter.
    2002. “Gender Equity in Theories of Fertility Transition.” Population and Development Review 26(3): 427–39.
    OpenUrl
  25. ↵
    Mills, Melinda C. 2011. Introducing Survival and Event History Analysis. Menlo Park, Calif.: Sage Publications.
  26. ↵
    Mills, Melinda C., Hans-Peter Blossfeld, and Erik Klijzing. 2005. “Becoming an Adult in Uncertain Times.” In Globalization, Uncertainty and Youth in Society, edited by H. P. Blossfeld, Erik Klijzing, Melinda Mills, and Karin Kurz. London: Routledge.
  27. ↵
    1. Mills, Melinda C.,
    2. Ronald R. Rindfuss,
    3. Peter McDonald, and
    4. Egbert te Velde.
    2011. “Why Do People Postpone Parenthood? Reasons and Social Policy Incentives.” Human Reproduction Update 17(6): 848–60.
    OpenUrlCrossRefPubMedWeb of Science
  28. ↵
    1. Mills, Melinda C., and
    2. Felix C. Tropf.
    2016. “The Biodemography of Fertility: A Review and Future Research Frontiers.” Special Issue, Kölner Zeitschrift für Soziologie und Sozialpsychologie 55(Demography): 397–424.
    OpenUrl
  29. ↵
    1. Moayyeri, Alireza,
    2. Christopher J. Hammond,
    3. Anna M. Valdes, and
    4. Timothy D. Spector.
    2013. “Cohort Profile: TwinsUK and Healthy Ageing Twin Study.” International Journal of Epidemiology 42(1): 76–85.
    OpenUrlCrossRefPubMedWeb of Science
  30. ↵
    1. Mostafavi, Hakhamanesh,
    2. Tomaz Berisa,
    3. Felix Day,
    4. John Perry,
    5. Molly Przeworski, and
    6. Joseph K. Pickrell.
    2017. “Identifying Genetic Variants that Affect Viability in Large Cohorts.” PLoS Biology 15(9): e2002458.
    OpenUrl
  31. ↵
    1. Murphy, Michael.
    1993. “The Contraceptive Pill and Women’s Employment as Factors in Fertility Change in Britain 1963–1980: A Challenge to the Conventional View.” Population Studies 47(2): 221–43.
    OpenUrlCrossRefPubMed
  32. ↵
    1. Okbay, Aysu,
    2. Bart M. L. Baselmans,
    3. Jan-Emmanuel De Neve,
    4. Patrick Turley, et al, .
    2016. “Genetic Variants Associated with Subjective Well-Being, Depressive Symptoms, and Neuroticism Identified through Genome-Wide Analyses.” Nature Genetics 48(6): 624–33.
    OpenUrlCrossRefPubMed
  33. ↵
    1. Okbay, Aysu,
    2. Jonathan P. Beauchamp,
    3. Mark A. Fontana,
    4. James J. Lee, et al, .
    2016. “Genome-Wide Association Study Identifies 74 Loci Associated with Educational Attainment.” Nature 533(7604): 539–42.
    OpenUrlCrossRefPubMed
  34. ↵
    1. Polderman, Tinca J. C.,
    2. Beben Benyamin,
    3. Christiaan A. de Leeuw,
    4. Patrick F. Sullivan,
    5. Arjen van Bochoven,
    6. Peter M. Visscher, and
    7. Danielle Posthuma.
    2015. “Meta-Analysis of the Heritability of Human Traits Based on Fifty Years of Twin Studies.” Nature Genetics 47(7): 702–09.
    OpenUrlCrossRefPubMed
  35. ↵
    1. Purcell, Shaun,
    2. Benjamin M. Neale,
    3. Kathe Todd-Brown,
    4. Lori Thomas,
    5. Manuel A. R. Ferreira,
    6. David Bender,
    7. Julian Maller,
    8. Paul I. W. de Bakker,
    9. Mark Daly, and
    10. Pak C. Sham.
    2007. “PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses.” American Journal of Human Genetics 81(3): 559–75.
    OpenUrlCrossRefPubMed
  36. ↵
    1. Rietveld, Cornelius A.,
    2. Sarah E. Medland,
    3. Jaime Derringer,
    4. Jian Yang, et al, .
    2013. “GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment.” Science 340(6139): 1467–71.
    OpenUrlAbstract/FREE Full Text
  37. ↵
    1. Rindfuss, Ronald R.,
    2. S. Philip Morgan, and
    3. Kate Offutt.
    1996. “Education and Changing Age Pattern of American Fertility: 1963–1989.” Demography 33(3): 277–90.
    OpenUrlCrossRefPubMedWeb of Science
  38. ↵
    1. Rodgers, Joseph Lee,
    2. Kimberly Hughes,
    3. Hans-Peter Kohler,
    4. Kaare Christensen,
    5. Debby Doughty,
    6. David C. Rowe, and
    7. Warren B. Miller.
    2001. “Genetic Influence Helps Explain Variation in Human Fertility: Evidence from Recent Behavioral and Molecular Genetic Studies.” Current Directions in Psychological Science 10(5): 184–88.
    OpenUrlCrossRef
  39. ↵
    1. Tropf, Felix C.,
    2. Nicola Barban,
    3. Melinda C. Mills,
    4. Harold Snieder, and
    5. Jornt J. Mandemakers.
    2015. “Genetic Influence on Age at First Birth of Female Twins Born in the UK, 1919–68.” Population Studies 69(2): 129–45.
    OpenUrlCrossRefPubMed
  40. ↵
    1. Tropf, Felix C., and
    2. Jornt J. Mandemakers.
    2017. “Is the Association Between Education and Fertility Postponement Causal? The Role of Family Background Factors.” Demography 54(1): 71–91. Accessed May 11, 2017. http://link.springer.com/10.1007/s13524-016-0531-5.
    OpenUrl
    1. Tropf, Felix C.,
    2. Gert Stulp,
    3. Nicola Barban,
    4. Peter M. Visscher,
    5. Jian Yang,
    6. Harold Snieder, and
    7. Melinda C. Mills.
    2015. “Human Fertility, Molecular Genetics, and Natural Selection in Modern Societies.” PloS One 10(6): e0126821.
    OpenUrlCrossRefPubMed
  41. ↵
    1. Tropf, Felix C.,
    2. Renske M. Verweija,
    3. Peter J. van der Most,
    4. Gert Stulp, et al, .
    2017. “Hidden Heritability Due to Heterogeneity Across Seven Populations.” Nature Human Behavior 1(10): 757–65.
    OpenUrl
  42. ↵
    1. Verweij, Renske M.,
    2. Melinda C. Mills,
    3. Felix C. Tropf,
    4. René Veenstra,
    5. Anastasia Nyman, and
    6. Harold Snieder.
    2017. “Sexual Dimorphism in the Genetic Influence on Human Childlessness.” European Journal of Human Genetics 25 (9): 1067–74.
    OpenUrl
  43. ↵
    1. Yang, Jian,
    2. Andrew Bakshi,
    3. Zhihong Zhu,
    4. Gibran Hemani, et al, .
    2015. “Genome-Wide Genetic Homogeneity Between Sexes and Populations for Human Height and Body Mass Index.” Human Molecular Genetics 24(25): 7445–49.
    OpenUrlCrossRefPubMed
  44. ↵
    1. Yang, Jian,
    2. Beben Benyamin,
    3. Brian P. McEvoy,
    4. Scott Gordon, et al, .
    2010. “Common SNPs Explain a Large Proportion of the Heritability for Human Height.” Nature Genetics 42(7): 565–69.
    OpenUrlCrossRefPubMedWeb of Science
  45. ↵
    1. Yang, Jian,
    2. S. Hong Lee,
    3. Michael E. Goddard, and
    4. Peter M. Visscher.
    2011. “GCTA: A Tool for Genome-Wide Complex Trait Analysis.” American Journal of Human Genetics 88(1): 76–82.
    OpenUrlCrossRefPubMed
  46. ↵
    1. Zhu, Zhihong,
    2. Andrew Bakshi,
    3. Anna A. E. Vinkhuyzen,
    4. Gibran Hemani, et al, .
    2015. “Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits.” American Journal of Human Genetics 96(3): 377–85.
    OpenUrlCrossRefPubMed
  47. ↵
    1. Zietsch, Brendan P.,
    2. Ralf Kuja-Halkola,
    3. Hasse Walum, and
    4. Karin J. Verweij.
    2014. “Perfect Genetic Correlation Between Number of Offspring and Grandoffspring in an Industrialized Human Population.” Proceedings of the National Academy of Sciences 111(3): 1032–36.
    OpenUrlAbstract/FREE Full Text
  48. ↵
    1. Zuk, Or,
    2. Eliana Hechter,
    3. Shamil R. Sunyaev, and
    4. Eric S. Lander.
    2012. “The Mystery of Missing Heritability: Genetic Interactions Create Phantom Heritability.” Proceedings of the National Academy of Sciences 109(4): 1193–98.
    OpenUrlAbstract/FREE Full Text
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RSF: The Russell Sage Foundation Journal of the Social Sciences: 4 (4)
RSF: The Russell Sage Foundation Journal of the Social Sciences
Vol. 4, Issue 4
1 Apr 2018
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The Sociogenomics of Polygenic Scores of Reproductive Behavior and Their Relationship to Other Fertility Traits
Melinda C. Mills, Nicola Barban, Felix C. Tropf
RSF: The Russell Sage Foundation Journal of the Social Sciences Apr 2018, 4 (4) 122-136; DOI: 10.7758/RSF.2018.4.4.07

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The Sociogenomics of Polygenic Scores of Reproductive Behavior and Their Relationship to Other Fertility Traits
Melinda C. Mills, Nicola Barban, Felix C. Tropf
RSF: The Russell Sage Foundation Journal of the Social Sciences Apr 2018, 4 (4) 122-136; DOI: 10.7758/RSF.2018.4.4.07
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  • Article
    • Abstract
    • CENTRAL EXPLANATIONS OF REPRODUCTIVE BEHAVIOR
    • DATA
    • HRS
    • STR
    • CONSTRUCTING LINEAR POLYGENIC SCORES OF REPRODUCTION
    • OTHER FERTILITY-RELATED TRAITS
    • SENSITIVITY TESTS
    • DISCUSSION AND CONCLUSION
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Keywords

  • human reproduction
  • polygenic scores
  • genetics
  • educational attainment
  • age at first birth
  • number of children ever born
  • fertility

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