A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
…, RE Denroche, SB Liang, AMK Brown, JC Kim… - Nature, 2016 - nature.com
Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development 1 . The current model of …
exemplifies the classically held view of stepwise cancer development 1 . The current model of …
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
…, YM Kim, M Seo, JJ Seo, D Park, Y Ko, I Choi, R Kim… - Nature medicine, 2013 - nature.com
New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread
of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, …
of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, …
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution
Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients.
The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor …
The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor …
[HTML][HTML] High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors
…, D Fenistein, M Contreras-Dominguez, J Kim… - PLoS …, 2009 - journals.plos.org
A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB),
is its ability to survive and multiply within macrophages, making these host cells an …
is its ability to survive and multiply within macrophages, making these host cells an …
Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism
Inherited disorders of vitamin B 12 (cobalamin) have provided important clues to how this
vitamin, which is essential for hematological and neurological function, is transported and …
vitamin, which is essential for hematological and neurological function, is transported and …
Workplace flexibility and worker well‐being by gender
Objective The study examines the associations between two distinct forms of workplace
flexibility—flexible schedules and working at home—and workers' well‐being, with special …
flexibility—flexible schedules and working at home—and workers' well‐being, with special …
Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti …
S Kang, RY Kim, MJ Seo, S Lee, YM Kim… - Journal of medicinal …, 2014 - ACS Publications
A critical unmet clinical need to combat the global tuberculosis epidemic is the development
of potent agents capable of reducing the time of multi-drug-resistant (MDR) and extensively-…
of potent agents capable of reducing the time of multi-drug-resistant (MDR) and extensively-…
[PDF][PDF] Truncating erythropoietin receptor rearrangements in acute lymphoblastic leukemia
I Iacobucci, Y Li, KG Roberts, SM Dobson, JC Kim… - Cancer cell, 2016 - cell.com
Chromosomal rearrangements are a hallmark of acute lymphoblastic leukemia (ALL) and
are important ALL initiating events. We describe four different rearrangements of the …
are important ALL initiating events. We describe four different rearrangements of the …
[HTML][HTML] Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia
In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors (TKIs),
especially in the absence of kinase domain mutations in BCR-ABL1, is poorly …
especially in the absence of kinase domain mutations in BCR-ABL1, is poorly …
[PDF][PDF] Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome
Genitopatellar syndrome (GPS) is a skeletal dysplasia with cerebral and genital anomalies
for which the molecular basis has not yet been determined. By exome sequencing, we found …
for which the molecular basis has not yet been determined. By exome sequencing, we found …