We examined how the migration and acculturation experiences of first-generation Latino youth contributed to their psychological well-being. Data came from the LAMHA (Latino Adolescent Migration, Health, and Adaptation) study, which surveyed 281 first-generation Latino immigrant youth, ages 12 to 19. Using logistic regression, we evaluated how migration stressors (i.e., traumatic events, choice of migration, discrimination, and documentation status) and migration supports (i.e. family and teacher support, acculturation, and personal-motivation) were associated with depressive symptoms and anxiety. We found that migration stressors increased the risk of both depressive symptoms and anxiety. Time in the United States and support from family and teachers reduced the risk of depressive symptoms and anxiety. Compared with documented adolescents, undocumented adolescents were at greater risk of anxiety, and children in mixed-status families were at greater risk of anxiety and marginally greater risk of depressive symptoms.